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KMID : 0369819850150020063
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Jorunal of Korean Pharmaceutical Sciences
1985 Volume.15 No. 2 p.63 ~ p.72
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Studies on Efficacy of Combined Preparation of Crude Drugs(XXIII) -Analgesic, Anticonvulsive, Sedative, Antipyretic Actions of Yangkyuksanwhatang and its Effects on Isolated Ileum and Blood Vessel
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Hong Nam-Doo
Kim Jong-Woo
Song Il-Byung
Won Do-Hee
Kim Nam-Jae
Kim Jin-Sung
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Abstract
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Analgesic, anticonvulsive, sedative and antipyretic actions of Yangkyuksanwhatang which is composed of nine crude drugs including Rehmanniae Radix, and its effects on isolated ileum and blood vessel were investigated. The results of the studies were summerized as follows; 1. Analgesic and antipyretic effects were observed. 2. Suppressive actions were not shown on the convulsion induced by strychnine, but significant effects were noted on the convulsion induced by picrotoxin. 3. A prolongation of anesthetic time induced by pentobarbital sodium was significantly observed. 4. Relaxing actions were noted on the ileum of mice, and also, same effects were recognized on the contraction of the ileum due to acetylcholine chloride and barium chloride. 5. The expansion of blood vessels by relaxation of smooth muscle and hypotensive effects were noted.
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